Tak Wah Mak

由 sufang 在 日, 11/02/2014 - 11:09 發表 Pre-published Cancer Metabolism Notes

Youtube https://www.youtube.com/watch?v=nFelWNxpdWk

Genomic alterations in cancers
mutations (300,000; > 20,000 genes)
epithelial : 50-100; leukemia: 20
amplifications (3000)
deletions (thousands)
translocations (fusions: 7000)
epigenetic changes (extensive)
Drivers : hundred, 90% loss of functions
Inter-and intra-tumor heterogeneity (Charles Sweton)
< 1/2 mutated or amplified genes expressed