大家好:
小龍年前最後一次journal club 要跟大家分享的paper 請下載連結檔案。Title: Fibroblast Growth Factor Receptor 3 (FGFR3) Is a Strong Heat Shock Protein 90 (Hsp90) Client
Jan 29, 2013
Jan 21, 2013
20130122 Journal Club Paper
大家好，
連結檔案是我這週要報告的paper，請查收，謝謝！
Title: Activation of TGF-b Pathway by Areca Nut Constituents: A Possible Cause of Oral Submucous Fibrosi.
連結檔案是我這週要報告的paper，請查收，謝謝！
Title: Activation of TGF-b Pathway by Areca Nut Constituents: A Possible Cause of Oral Submucous Fibrosi.
Jan 17, 2013
20130116Lab meeting-小丸
1. 利用pooled shDDR1 clones探討DDR1對於OSCC cells的影響，結果發現抑制DDR1表達造成OSCC cells數目降低及細胞凋亡數目增加，而p-SHC、p-SHP2、p-MAPK、CDK1及bcl2為參與DDR1 pro-survival 路徑的重要分子。
2. 比較一系列DDR1 inhibitors (Imatinib、Dasatinib及Nilotinib )對於OSCC cells生長的影響，其中Dasatinib對於OSCC cells的生長抑制效果顯著，但其為廣效型抑制劑，相較之下對DDR1專一性較差，因此，之後實驗仍會著重於Imatinib及Nilotinib當作DDR1抑制劑，觀察對於OSCC cells生長的影響。
3. 利用HOK探討collagens是否會增加DDR1及collagens的protein及mRNA level表達，結果發現collagen typeIV扮演重要角色。
2. 比較一系列DDR1 inhibitors (Imatinib、Dasatinib及Nilotinib )對於OSCC cells生長的影響，其中Dasatinib對於OSCC cells的生長抑制效果顯著，但其為廣效型抑制劑，相較之下對DDR1專一性較差，因此，之後實驗仍會著重於Imatinib及Nilotinib當作DDR1抑制劑，觀察對於OSCC cells生長的影響。
3. 利用HOK探討collagens是否會增加DDR1及collagens的protein及mRNA level表達，結果發現collagen typeIV扮演重要角色。
Jan 10, 2013
Jan 5, 2013
DDR1, Integrin, Cell adhesion and more...
Discoidin Domain Receptors Promote α1β1- and α2β1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation. (PLoS One. 2012;7(12):e52209)
Xu H, Bihan D, Chang F, Huang PH, Farndale RW, Leitinger B.
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that bind to and are activated by collagens. Similar to collagen-binding β1 integrins, the DDRs bind to specific motifs within the collagen triple helix. However, these two types of collagen receptors recognize distinct collagen sequences...
Xu H, Bihan D, Chang F, Huang PH, Farndale RW, Leitinger B.
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that bind to and are activated by collagens. Similar to collagen-binding β1 integrins, the DDRs bind to specific motifs within the collagen triple helix. However, these two types of collagen receptors recognize distinct collagen sequences...
Jan 2, 2013
20130102 Journal Club Paper
Dear all,
Attached is (link me here) the paper I will present next Tuesday, please received. W-H Lee
Title: AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells
Title: AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells
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