補遺：mir-17-92 cluster

 mir-17-92 cluster是由MIR17HG這個gene transcribed出來的：

MIR17HG: This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster.

UCSC連結

MIR17HG全長為6756bp,裡面的六各microRNA precusors位置從

mir-17 (chr13:92,002,859)
mir-18a (chr13:92,003,005)
mir-19a (chr13:92,003,145)
mir-20a  (chr13:92,003,319)
mir-19b-1 (chr13:92,003,446)
mir-92a-1 (chr13:92,003,568)

UCSC連結

彼此靠得非常近，總結來說，他們來自a single primary transcript，受到相同的調控，沒有獨自的promoter。

2013/02/26 journal club paper

大家好：
      開春第一報，title: Leukemia cell to endothelial cell communication via exosomal miRNAs，連結。
                                                                                                                                                         

補遺

殘念desu, bladder cancer cell line RT-112的fusion band和wild type其實不太好分。