2016/105年待辦事項

2016/105年待辦事項

由 sufang 在 三, 05/27/2015 - 08:45 發表 Pre-published Gene Fusion HOK Lin Lab Oral Cancer

Paper Submission

宛樺: DDR1 overexpression in OSCC 

嬿如: EBV Rta mediated DNA methylation in the host genome

 

FGFR Gene Fusion related (玉蓮、奕宏)

1. FGFR2 gene fusion in cholangiocarcinoma (Post 連結)

2. FGFR3 gene fusion in oral cancer (Post 連結)

 

Carcinogen induced epigenetic transformation in human oral keratinocytes (嬿如、英潔)

1. Molas analysis of RNA-Seq data (Post 連結)

2. MTHFR SNPs and epigenetic transformation

3. Develop methylation markers for head and neck patients

 

Mutational landscape of cholangiocarcinoma (Post 連結)

 

Mutational landscape of OSPCC and Oral Cancer (Post 連結)

 

Grant Proposal and Report

1. 104-CAPP05

    月報 x 12 (in progress)

    期中報告 (done by 佩瑩)

    期末報告

2. 105-CAPP  執行與考核點設定

3. 106-CAPP  計畫書撰寫

4. MOHW 衛福部OPMD計畫

    實驗進行 (記得送OSCC DNA給Jeffrey Lab. 一併測試MTHFR)

5. 105-MOST 科技部計畫 (11月中 call for proposal)

6. 105-MOST PPG (LOI submitted)

Reading Notes

Wiki  Biological action (2015/05/17)

In many Asian cultures, the areca nut is chewed along with betel leaf to obtain a stimulating effect. Arecoline is the primary active ingredient responsible for the central nervous system effects of the areca nut. Arecoline has been compared to nicotine; however, nicotine acts primarily on the nicotinic acetylcholine receptor. Arecoline is known to be a partial agonist of muscarinic acetylcholine M1, M2, M3 receptors and M4 which is believed to be the primary cause of its parasympathetic effects (such as pupillary constriction, bronchial constriction, etc.).

LD50: 100 mg/kg, administered subcutaneously in mouse.

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2015/05/25

pdf 4377 2014-Feb New nucleophilic mechanisms of ROS-dependent epigenetic modifications: comparison of aging and cancer

Igor Afanas'ev Vitamine Research Institute, Moscow, Russia, Poetom Portugal

ROS-induced DNA Methylation in Cancer 共舉12例