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Home for virtual meeting II (https://aacr20vm2.onlineeventpro.freeman.com/)
(MyAACR sflin1 | Gn9)
06/22 10:00-12:20 AM
SESSION PL01 - Opening Plenary Session: Turning Science into Lifesaving Care
Apr 27, 2020
2020 AACR Virtual Meeting - I (04/27 ~ 04/28)
AACR 2020 Virtual Meeting I
Virtual Meeting Announcement site (find abstracts easier in this site)
Search by "tumor microenvironment" ----> by Date ----> 04/27 nothing interesting
04/28 (https://www.abstractsonline.com/pp8/#!/9045/session/838)
Evaluating Cancer Genomics from Normal Tissues through Evolution to Metastatic Disease
Abstract
The human breast consists of lobules connected to an intricate network of ducts that are surrounded by fatty tissues, designed to produce and transport milk to nourish offspring. Histopathology has identified 10 major cell types based on morphological features but have provided limited information on cell states - the transcriptional programs of cell types that reflect different biological functions. In this study we have generated an unbiased ‘cell atlas’ of the normal human breast to define the cell types and cell states using single cell RNA sequencing and spatial transcriptomics methods. We performed 3’ microdroplet based single cell and nuclei RNA sequencing of 248,687 stromal cells and 89,301 nuclei from 24 women with pathologically normal breast tissues that were collected from mastectomies and reduction mammoplasties. Unbiased expression analysis identified four major cell types: adipocytes, epithelial cells (luminal and basal), fibroblasts and endothelial cells and defined their transcriptional programs. Additionally, 8 minor cell types were identified in the breast, including macrophages, T-cells, natural killer cells, mast cells, pericytes, apocrine cells, neurons and smooth muscle cells. Our data revealed hundreds of novel markers of these cell types and defined their transcriptional programs and cell states. Most cell types had multiple transcriptional programs including luminal epithelial cells (hormone receptor positive and secretory), basal epithelial cells (myoepithelial or basal), endothelial cells (E1, E2, E3), myeloid cells, T-cells and fibroblasts (F1-F4) and provided insight into developmental lineages. We further delineated the spatial organization of these cell types and cell states within the tissue architecture using spatial transcriptomics assay. The breast cell atlas data provides an invaluable normal reference for the research community to understand how normal cell types are reprogrammed in diseases such as breast cancer.
Virtual Meeting Announcement site (find abstracts easier in this site)
Search by "tumor microenvironment" ----> by Date ----> 04/27 nothing interesting
04/28 (https://www.abstractsonline.com/pp8/#!/9045/session/838)
Evaluating Cancer Genomics from Normal Tissues through Evolution to Metastatic Disease
- 5702 - A spatially resolved single cell atlas of the human breast (Tapsi Kumar & Kai Kessenbrock)
Feb 13, 2020
2020/02/20 Journal Club
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.
Jan 30, 2020
2020/02/06 Journal Club
Programmable bacteria induce durable tumor regression and systemic antitumor immunity.
Jan 10, 2020
Jan 6, 2020
2020/01/09 Journal Club
An Interleukin-25-Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation.
Nov 22, 2019
Nov 8, 2019
Oct 24, 2019
2019/10/31 Journal Club
Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer.
Oct 15, 2019
2019/10/17 Journal Club
Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis.
Sep 18, 2019
2019/09/26 Journal Club
Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status.
Sep 5, 2019
2019/09/12 Journal Club
Placental growth factor regulates the generation of TH17 cells to link angiogenesis with autoimmunity.
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