Mar 21, 2017

Mitochondrial function provides instructive signals for activation-induced B-cell fates.

(PubMed連結: 25857523)

Ming-YuのSlides <按我預覽或下載>

Mar 9, 2017

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

(PubMed 連結)

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Yun-Hsin Slide <按我預覽或下載>

Feb 24, 2017

The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.

(PubMed連結)
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Yi-Chen slide 按我預覽或下載
Yi-Chen 補充說明slide 按我預覽或下載

Feb 17, 2017

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

<PubMed連結>

Wei-Chanの slide <按我預覽或下載>

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2014/06/20 咦, 有PubPeer alert呦...
Christos Chinopoulos | Jun 20 2014 05:48 EST

Could it be that LPS-induced succinate over-production is due to itaconate formation? LPS induces Irg1, a gene coding for cis-aconitate decarboxylase, specifically expressed in cells of macrophage lineage Proc Natl Acad Sci U S A. 2013 May 7;110(19):7820-5. doi: 10.1073/pnas.1218599110, yielding itaconate. Itaconate is preferentially used by succinyl CoA ligase forming itaconyl CoA, thus generating an accumulation of succinate when the ligase operates towards succinyl CoA formation ADLER J, WANG SF, & Lardy HA (1957) The metabolism of itaconic acid by liver mitochondria. J. Biol. Chem, 229, 865-879, and WANG SF, ADLER J, & Lardy HA (1961) The pathway of itaconate metabolism by liver mitochondria. J. Biol. Chem, 236, 26-30. http://www.ncbi.nlm.nih.gov/pubmed/23535595#cm23535595_4939

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2017/02/23 奕宏問了一個好問題, 抱歉, 我回來想想我當場的解釋並不正確, 現在重來一次! Orz...

Suppl Fig 15

奕宏問說, 既然IL1B是HIF1A(a transcription factor)的下游, 何以兩者的表現量未呈正相關?

我原先回答說transcript regulation level(IL1B)和protein regulation level (HIF1A)不同, 不用這樣子一起比。但是，仔細看著它們，既然細胞是一樣的，不管受什麼level調節，兩者應該要同上同下才對，因為它們的context是相同的。

因此，剩下的唯一可能應是使用diethylsuccinate(DS)和butylmalonate(BM)所造成的差異。例如，BM除了induce HIF1A stabilization以外，還有stabilize其它IL1B之上游分子，而那些因子在DS那一組並未出現。如此便可解釋為何HIF1A和IL1B在兩種藥處理下，蛋白量並未成正相關。 How do you like this idea, Yi-Hong? 😀

Jan 24, 2017

2017/02/02 Journal Club paper

Indomethacin Treatment of Mice with Premalignant Oral Lesions Sustains Cytokine Production and Slows Progression to Cancer.

< PubMed 連結> PMID: 27713748

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奕宏報告的PPT檔按我預覽或下載

奕宏補充報告PPT檔按我預覽或下載

Jan 4, 2017

2017/1/12 Journal Club Paper

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps.

PubMed 連結

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秀鈴 transformed the PPT file to two PDF because it's too huge to be attached. Best, SL

PDF1 (按我預覽或下載) PDF2 (按我預覽或下載)

The Schedule

Place: R2-3042; Time: 12:00-14:00; 30 min presentation + 30-40 min discussion

Please send the title and the PDF file of the paper being presented to all the members one week before the talk.
輪到你的時候，請在一周前把題目及pdf檔寄給大家謝謝。

For 奕宏 talk at "I Love Immunology" on 2/2

Dear 奕宏: 我覺得#4在講premalignant lesion和PGE2 (https://goo.gl/RjzJaX) 那篇不錯。

另外，這裡有作者簡介的新聞 PUBLIC RELEASE: 30-NOV-2016

I get by with help from my friends: Maintaining immune cells in head and neck cancer (https://goo.gl/FCs7Gg）

Dec 21, 2016

參加人員名單暫存區

黃麗蓉 Lab

鄭雲心 <cloudheard@gmail.com>,

陳宥婕 <Emilyycchen@nhri.org.tw>,
黃麗蓉 < lrhuang@nhri.org.tw>,

蘇郁文 Lab

徐偉展 <weichanhsu@nhri.org.tw>,

陳明玉 <cmy6075@nhri.org.tw>,

蘇郁文 <yuwensu@nhri.org.tw>,

許素菁 Lab

簡秀鈴 <sljian@nhri.org.tw>,

李宜珍 <ycli@nhri.org.tw>,
王復輝 <fhwang0919@gmail.com>,
莊雯婷 <chuangwenting@gmail.com>,

許素菁 <mschsu@nhri.org.tw>,

林素芳 Lab

劉奕宏 <haloedition8@gmail.com>,

柯英潔 <ingridko0128@gmail.com>,

陳玉蓮 <lanie0407@gmail.com>,

林素芳 <sflin@nhri.org.tw>

Aug 1, 2016

17th Biennial EBV Meeting @ Switzerland (Aug/8-Aug/12)

有些abstract已被剪到GRC NPC個人檔案中

Monday, 2016/08/08
Session 1: EBV epidemiology and sequence variation 2:30pm-
Chairpersons:
Henri-Jacques Delecluse, German Cancer Research Institute, Heidelberg, Germany 
Alan Chiang, University of Hong Kong, China

Heterogeneity of the major internal repeat (IR1) of Epstein-Barr virus implicates interstrain recombination in pathogenesis, and includes a nonsense mutation of EBNA-LP in the prototype strain B95-8. Mohammed Ba Abdullah, Imperial College London, UK
High levels of antibody that neutralize B-cell infection of Epstein-Barr virus and that bind EBV gp350 are associated with a lower risk of nasopharyngeal carcinoma  Anna Coghill, National Cancer Institute, Bethesda, USA
Development of highly efficient and widely applicable CRISPR/Cas9-mediated cloning method of EBV genomes and its application to EBV-positive gastric cancer cell lines  Teru Kanda, Aichi Cancer Center Research Institute, Nagoya, Japan
Association between cigarette smoking and oral EBV viral loads in China: a multicenter cross sectional study in 2013-2016  Weihua Jia, Sun Yat-Sen University Cancer Center, Guangzhou, China
Determination and Genome-wide Analysis of EBV Sequences in EBV- associated Gastric Carcinoma from Guangdong, an endemic area of nasopharyngeal carcinoma  Chun-kui Shao, Sun Yat-Sen University, Guangzhou, China
The dominating promoter variation of BRLF1 in nasopharyngeal carcinoma endemic area contributes to high efficacy of Epstein-Barr virus reactivation Jiangbo Zhang, Sun Yat-Sen University Cancer Center, Guangzhou, China

獵頭職場真相觀察

老闆要2個業務聯絡200個客戶...為什麼打完100通電話、「聽話」的人反而被解僱？
<撰文者江湖人稱S姐> 出處商業週刊按我

這是兩位業務在剛開始要做客戶開發時遇到的故事，可以拿來當借鏡。兩位員工暫且稱為小劉和小王好了，而這位主管的管理方式喜歡訓練員工思考。

主管：手邊這200個客戶跟聯繫窗口，你們分別聯繫100個，一周後我們來討論狀態。

小劉：好，我現在立馬來做。

小王 : 這100個名單裡面，哪些是比較重要但被忽略的客戶？哪些是久沒連繫的客戶？

討論一番以後，隔了一周，主管開會時分別和兩位業務詢問客戶狀態。

Our Thoughts (桀靜精微雷風相薄)

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