2017/09/28 Journal Club

Gsk3 is a metabolic checkpoint regulator in B cells.

PubMed Link

2017/08/31 Journal Club

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.

(PubMed Link)

2017/08/17 Journal Club

Serine Is an Essential Metabolite for Effector T Cell Expansion.

(PubMed Link)

2017/07/20 Journal Club

Enrichment of Human CCR6+ Regulatory T Cells with Superior Suppressive Activity in Oral Cancer.

(PubMed Link)

Yi-Hong's slides : 按我預覽或下載

2017/07/06 Journal Club

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.

<PubMed Link>

2017/06/22 Journal Club

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

<PubMed Link>

Ming-Yu slides <按我預覽或下載>

2017/06/08 Journal Club

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.

PubMed Link

Yun-Hsin slides 1 : 按我預覽或下載
Yun-Hsin slides 2_questions : 按我預覽或下載

2017/05/11 Journal Club

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

PubMed Link

Wei-Chan的slides <按我預覽或下載>

2017/04/27 Journal Club

PI3Kγ is a molecular switch that controls immune suppression.

(PubMed Link)

------------------------
Yi-Hongのslides  <按我預覽或下載>

2017/06/26 Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells 講者：許銘娟 博士 ( Dr.洪副實驗室博士後研究員 後來颱風取消)

2017/04/13 Journal Club

A Myc-dependent division timer complements a cell-death timer to regulate Tcell and B cell responses.

 (PubMed連結: 27820810)

___________________
SL的slides <按我預覽或下載>

Interesting paper found? Please deposit it here. Thank You.

If you found any interesting story and want to share with us, please drop the PubMed pmid or title of the paper by replying to the 'comments'. I will 'lift' it to the post content, assign an id and make link for the paper. Thank you.  Su-Fang

1. Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow. (2018/08 Cell Rep) 
2. A New Perspective: Exploring Future Therapeutic Strategies For Cancer By Understanding The Dual Role Of B Lymphocytes In Tumor Immunity. (2018/ Int J Cancer)
   
3. IFNg-Dependent Tissue-Immune Homeostasis Is Co- opted in the Tumor Microenvironment (2017/06 Cell)
4. Interferon-g Drives Treg Fragility to Promote Anti- tumor Immunity (2017/06 Cell)
5. Targeting tumor-infiltrating Ly6G1 myeloid cells improves sorafenib efficacy in mouse orthotopic hepatocellular carcinoma (2017/12 Int J Cancer, NTUH)
6. Eight-Color Multiplex Immunohistochemistry for Simultaneous Detection of Multiple Immune Checkpoint Molecules within the Tumor Microenvironment (2018/01 J Immunol)
7. Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients. (2017/12 J Pathol)
8. Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient (2017/08 Cell )
9. Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution (2017/11 Cell)
10. MHC-I Genotype Restricts the Oncogenic Mutational Landscape (2017/11 Cell)
11. Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy (2017/12 Science)
12. Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts (2017/12 Cell Reports)
13. Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases (2017/12 Oncogene)
14. An immunogenic personal neoantigen vaccine for patients with melanoma (cancer vaccine 1/2, Catherine Wu group 28678778) 
15. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer (cancer vaccine 2/2, Ugur Sahin group 28678784)
16. An immune atlas of clear cell renal cell carcinoma (using CyTOF to detect TILs 28475899) 
17. Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses (using scRNA-seq to detect TILs 28475900)
18. 麗蓉老師推薦 Effective combinatorial immunotherapy for castration-resistant prostate cancer (Ronald A. DePinho 且有 CyTOF) (28321130) (Erratum)
19. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. (11323675)
20. XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer. (25893296)
21. CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma. (27265504)
22. Indomethacin Treatment of Mice with Premalignant Oral Lesions Sustains Cytokine Production and Slows Progression to Cancer. (27713748) 
23. Metastasis: Pathways of parallel progression (27974802)(27974799)(27974798).

2017/03/30 Journal Club

Mitochondrial function provides instructive signals for activation-induced B-cell fates.

(PubMed連結: 25857523)

 Ming-YuのSlides <按我預覽或下載>