2018 GRC NPC Index page

0624 (Sunday night)

• Prof George SW Tsao: 186 participants (66 China, 44 Hong Kong, 20 Industry)
• Keynote Session: Viruses, Cancer and Stem Cell [06/24 PM]
• led by Alan Rickinson (University of Birmingham, United Kingdom)
• In memory of Thomas Turse 1946-2018 (start to work on EBV since 1979s’ ; an oncologist; stromatolites-tumor in NPC; organizer of EBV meeting at Annecy France in 1994)

Patric Moore (Why Do Viruses Cause Cancer?)
Irving Weissman (Normal and Neoplastic Stem Cells)

0625 Monday (Day 2)

• EBV Infection and NPC Pathogenesis [06/25 AM]
• led by Alan Chiang (The University of Hong Kong, Hong Kong SAR China)

Paul Farrell (EBV Genome Sequence Variation: Geography, Function and Disease)
Bill Sugden (How EBV Prevails During Productive Infection)
Rebecca Skalsky (regulation of Host Signaling Pathways by EBV miRNAs)
Bo Zhao (NPC Epigenetic Landscapes and Super-Enhancers)
Selected from Poster Abstracts:
Lin Feng (Nasopharyngeal carcinoma susceptibility gene TNFRSF19 inhibits TGFß signaling and promotes tumorigenesis)
Miao Xu (Genome sequencing analysis identifies Epstein- Barr virus subtypes associated with the risk of nasopharyngeal carcinoma)

• Regulation of Lytic and Latent EBV Infection [06/25 PM]
• led by Mei-Ru Chen (National Taiwan University, Taiwan)

Shannon Kenney (Differentiation-Dependent Lytic EBV Reactivation in Epithelial Cells)
Lori Frappier (New Functions for EBV Proteins in Manipulating Cellular Processes Important for Cancer)
Mu Sheng Zeng 曾木聖 (The Key Cellular Factors in EBV Infection of Epithelial Cells)

0626 Tuesday (Day 3)

• Risk Factors and Novel Markers for NPC [06/26 AM]
• led by Jin-Xin Bei 貝錦新 (Sun Yat-Sen University Cancer Center, China)

Wei-Hua Jia (Genetic Predisposition of Nasopharyngeal Carcinoma: Evidence from GWAS and Sequencing Studies)
Jin-Ching Lin 林進清 (Application of Plasma EBV DNA Assay in Daily Practice of NPC Management)
Dennis Lo 盧煜明 (Plasma EBV DNA for – Screening Nasopharyngeal Carcinoma)
Maria Lung (New Insights in NPC Detection Utilizing Circulating Tumor Cell Enumeration and NGS Analysis)
Scott Bratman (Circulating Tumor DNA: Detection and Applications in Curable Cancers)

• Molecular Profiling of NPC [06/26 PM]
• led by Andrew Futreal (University of Texas MD Anderson Cancer Center, USA)

Kwok Wai Lo 羅國煒 (Acquired Genomic Changes in Nasopharyngeal Carcinoma)
Wei Dai (Genetic Susceptibility in Nasopharyngeal Carcinoma)
Daniel De Carvalho (Translational Aspects of DNA Methylation in Cancer)
Selected from Poster Abstracts:
Ming-Han Tsai 蔡明翰 (The M81 Epstein-Barr Virus Associated RNA2 Enhances CXCL8 Production and Spontaneous Virus Lytic Replication in Primary B Lymphocytes)

0627 Wed (Day 4)

• Tumor Microenvironment of NPC [06/27 AM]
• led by Eric Stanbridge (University of California, Irvine, USA)

Pierre Busson (Galectin-9 and Other Factors of Immune Escape in NPC Tumor Microenvironment: How to Bring Them Under Control?)

Maria Massucci (A Role of Bacterial Co-Infection in the Pathogenesis of NPC?)
Selected from Poster Abstracts:
Alan Chiang
(Novel Mechanism of Induction of Lytic Cycle of Epstein-Barr Virus (EBV) in EBV-Positive Epithelial Malignancies Through Intracellular Iron Chelation)
Scott Bratman

(EBV-Seq for Ultrassensitive Detection of Nasopharynx Cancer from Plasma Cell-Free DNA)
Shibing Li

(ISNLx Regulates Cellular Metabolic Reprogramming and Is a Potential Therapeutic Target for Nasopharyngeal Carcinoma)
Jun Zhang
(Epstein-Barr Virus-Encoded LMP1 Reprograms Glucose Metabolism to Drive Cell Motility Through mTORC2/PDHE1α-Mediated Histone Acetylation in Nasopharyngeal Cells)
Xuefeng Liu (ROCK inhbibitor J Pathol Author, Georgetown U)
(Patient-Derived Cell Models and Next Generation Living Biobanks (NGLB) for Precision Medicine)
Dewi Kartikawati Paramita
(NPC Strip G: Rapid Test Strip Detecting IgG Against EBV Antigens in NPC)

• Challenges and Novel Approaches in NPC Treatment [06/27 PM]
• led by Brian O'Sullivan (University of Toronto, Canada)

Danny Rischin (Role of Chemotherapy in NPC: Not Novel, but Still Challenging)

Jun Ma 馬駿 (Comprehensive Treatment Strategy in Locoregionally Advanced Nasopharyngeal Carcinoma)

Anne Lee (Challenges and Novel Approaches in Radiotherapy for Nasopharyngeal Carcinoma)

Troy Messick (Development of an EBNA1 Inhibitor for the Treatment of NPC: Toward First-in- Human Studies)

0628 Thu (Day 5)

• Immunotherapy of NPC [06/28 AM]
• led by Dora Kwong 鄺麗雲 (University of Hong Kong, Hong Kong SAR China)

Lillian Siu (Immune and Other Biomarkers of Resistance to Anti-PD1 Therapy in NPC)
Rajiv Khanna (Adoptive T Cell Therapy for NPC: Immune Correlates to Immune Contexture)
Graham Taylor (The NPC Immunotherapy Landscape)
Han Chong Toh (Cellular Immunotherapy for Nasopharyngeal Cancer: Learning from the Past for a Better Tomorrow)
Brigette Ma (Immune Checkpoint Inhibitor in the Treatment of Nasopharyngeal Carcinoma: A Clinical Overview)

• Keynote Session: Future Perspectives in NPC Research and Treatment
• led by Quynh-Thu Le (Stanford University, USA)

Tak Mak (Beyond Targeting Oncogenes: Future Anti-Cancer Strategies)
Lawrence Young (The Future of NPC Research: Opportunities and Challenges)

Poster List

Poster I (6/25 4-6 PM)

#	Name	Affiliation	Co-Author(s)	Poster Title	Category
01	Abdul Aziz, Norazlin	Institute for Medical Research	Marini Marzuki, Nurul Ashikin Mohd Shahrehan, Susan Ling Ling Hoe, Lu Ping Tan, Geok Wee Tan, Noor Kaslina Mohd Kornain, Kin Choo Pua, Cheng Eng Koay, Chai Chiun Hian Sebastian Dominic Ling Chuo Shern	Histological and molecular characterization of nasopharyngeal carcinoma patient-derived xenografts	Translational
02	Aimjongjun, Sathid	Mahidol University	Muhammad Asaduzzaman, Shang Yao, Paula Saavedra- García, Tavan Janvilisri, Eric Wing-Fai Lam	Lapatinib resistance in nasopharyngeal carcinoma is mediated through Sirt2- modulated FOXO3 deacetylation	Basic
03	Baloche, Valentin	Gustave Roussy		Using the CT26 syngenic tumor model for basic and pre-clinical investigations on galectin-9, an immuno- suppressive protein abundantly expressed by malignant NPC cells	Translational
04	Bratman, Scott	Princess Margaret Cancer Centre	Jeffrey Bruce, Ting Ting Wang, Jinfeng Zou, Caberry WeiYang Yu, Marco Di Grappa, Zhen Zhao, Yanqiao Zheng, Shao Hui Huang, Trevor Pugh, John Waldron, Lillian Siu, Fei-Fei Liu	EBV-Seq for ultrasensitive detection of nasopharynx cancer from plasma cell- free DNA	Clinical
05	Cao, Sumei	Sun Yat-Sen University Cancer Center	Ting Hu, Qing Liu, Shang-Hang Xie, Chu- yang Lin, Geng-hang Chen	Smoking is associated with a persistent EBV reactivation and long-term increased nasopharyngeal carcinoma (NPC) risk: an analysis of a prospective NPC screening cohort in southern China	Clinical

06	Chai, Wai Yeeng	Cancer Research Malaysia	Sok Ching Cheong, Hui Mei Lee, Pei San Yee, Stacey Price, Emanuel Gonclaves, Fiona Behan, Ultan McDemott, Matthew Garnett	Genome-wide CRISPR- Cas9 knockout screen in EBV-positive NPC cell line reveals vulnerabilities to members of the NF/kB pathways	Basic
07	Chan, Tsz Fung	The University of Hong Kong	Hui KF, Shen JJ, Lam KP, Yang W and Chiang AK	Identification of several distinct clusters of type 1 and type 2 EBV harbored in Hong Kong Chinese carriers showing significant variations from EBV isolated from other geographic	Clinical
08	Chen, Chi- Ju	National Yang-Ming University	Dai-Rong He, Chong- Yu Chao, Hsin Guo	MSK1-mediated CREB activation is important for EBV reactivation	Basic
09	Chen, Lin	Sun Yat-Sen University Cancer Center	Jing Yuan, Jingshu Xiao, Lin Chen, Yi-Fan Lian, Xue-Kang Qi, Jin- Xin Bei, Yi-Xin Zeng, and Lin Feng.	SHROOM2 suppresses nasopharyngeal carcinoma metastasis by inhibiting epithelialmesenchymal transition in a RhoA-ROCK pathway-independent manner	Basic
10	Chen, Yupei	Sun Yat-Sen University Cancer Center	Ling-Long Tang, Qi Yang, Sharon-Shuxian Poh, Edwin P Hui, Anthony TC Chan, Whee-Sze Ong, Terence Tan, FRCR, Joseph Wee, Wen-Fei Li, Lei Chen, Brigette BY Ma, Macy Tong, Sze-Huey Tan, Shie	Induction chemotherapy plus concurrent chemoradiotherapy in endemic nasopharyngeal carcinoma: individual patient data pooled analysis of four randomized trials	Clinical
11	Cheong, Sok Ching	Cancer Research Malaysia		The use of dual-antigen peptide to stimulate immune responses in head and neck cancer patients	Translational
12	Chiang, Alan	The University of Hong Kong	Kwai Fung Hui, Pei Tung Yiu, Chung King Choi, Richard Yi Tsun Kao, Dan Yang	A novel mechanism of induction of lytic cycle of Epstein-Barr virus (EBV) in EBV-positive epithelial malignancies through intracellular iron chelation	Basic

13	Chung, Grace	The Chinese University of Hong Kong	Yvonne Yan-Yan Or, Zoey Wing-Yee Liu, Ka- Fai To, Kwok-Wai Lo	Epigenetic alterations of TGFß signaling pathway in EBV-associated nasopharyngeal carcinoma	Basic
14	Chiu, Ya- Fang	Chang Gung University	Arthur U. Sugden, Kathryn Fox, Mitchell Hayes, and Bill Sugden	Kaposi’s sarcoma– associated herpesvirus stably clusters its genomes across generations to maintain itself extrachromosomally	Basic
15	Dai, Danling	Sun Yat-Sen University Cancer Center	Ping Han, Mu-Sheng Zeng	Novel chimeric transcript RRM2-c2orf48 promotes metastasis in nasopharyngeal carcinoma	Basic
16	Daker, Maelinda	Institute for Medical Research	Paul Matthew Neilsen, Munirah Ahmad, Alan Soo-Beng Khoo	Silvestrol: a protein synthesis inhibitor as a potential targeted therapy against NPC	Basic
17	Deng, Mingdan	The University of Hong Kong	AKL Cheung, W Dai, HY Ng, ML Lung	Functional and molecular analysis of the somatic mutations in two NF-?B pathway inhibitors, NFKBIA and CYLD, in nasopharyngeal carcinoma	Basic
18	Du, Yun	Cancer Research Institute of Zhongshan City, Zhongshan City People's Hospital	Wentong Zhang, Feng Lei, Zhuming Li, Xiaodong Liu, Yanan Ni, Li Deng, Mingfang Ji	Long-term outcomes of intensity-modulated radiotherapy for nasopharyngeal carcinoma: a retrospective analysis of survival and treatment toxicities in a prefecture-level hospital in China	Clinical
19	Fachiroh, Jajah	Universitas Gadjah Mada	T. Baning Rahayujati, Suhada Suhda, Dwi Hartati, Camelia Herdini	Genetic and environmental risk factors of nasopharyngeal carcinoma in Indonesia	Clinical

20	Feng, Lin	Sun Yat-Sen University Cancer Center	Chengcheng Deng, Yuxin Lin, Xue-Kang Qi, Gui-Ping He, Yuchen Zhang, Hao-Jiong Zhang, Miao Xu, Qi- Sheng Feng, Jin-Xin Bei, Yi-Xin Zeng and Lin Feng	Nasopharyngeal carcinoma susceptibility gene TNFRSF19 inhibits TGFß signaling and promotes tumorigenesis	Basic
21	Feng, Ruimei	Sun Yat-Sen University Cancer Center	Ellen T. Chang, Zhiwei Liu, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian- Yong Shao, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yu	Reproductive history and risk of nasopharyngeal carcinoma based on a population-based case– control study in southern China	Clinical
22	Hau, Tom Pok Man	The Chinese University of Hong Kong	Kwok Wai Lo	Characterization of fusion protein UBR5-ZNF423 in nasopharyngeal epithelial cells	Basic
23	He, Yongqiao	State Key Laboratory of Oncology in South China	Wen-Qiong Xue, Jiang- Bo Zhang, Jianbing Mu, Wei-Hua Jia	The relationship between environmental factors and the profile of Epstein-Barr virus antibodies in the lytic and latent infection periods in healthy populations from endemic and non-endemic nasopharyn	Clinical
24	Hoe, Susan	Institute for Medical Research	Lu Ping Tan, Norazlin Abdul Aziz, Kitson Liew, Mohd. Firdaus Che Mat, Suziana Zaila Che Fauzi, Sin-Yeang Teow, Fazlyn Reeny Abdul Razak, Christine Ricky, Nurul Ashikin Mohamed Shahrehan, Tai Lin Chu	Patient-derived xenografts as preclinical models for cancer stem cells and therapeutic studies in NPC	Translational
25	Hu, Ting	Sun Yat-Sen University Cancer Center	Shang-Hang Xie, Chu- yang Lin, Geng-hang Chen, Su-Mei Cao	Smoking is associated with a persistent EBV reactivation and long-term increased nasopharyngeal carcinoma (NPC) risk: an analysis of a prospective NPC screening cohort in southern China	Clinical

26	Huang, Chor Mei	The University of Hong Kong	Anna CM Tsang	Promotion of In Vivo Growth of Epstein-Barr Virus (EBV)-associated Nasopharyngeal Carcinoma by miR-BARTs	Basic
27	Hui, Kwai Fung	The University of Hong Kong	AKS Chiang	Induction of Epstein-Barr virus lytic cycle in EBV- associated epithelial malignancies by dual actions of histone deacetylase inhibitors and a novel organic compound	Basic
28	Janvilisri, Tavan	Mahidol University	Sathid Aimjongjun, Onrapak Reamtong	Glycoproteomic comparison between nasopharyngeal carcinoma cells with different metastatic potential	Basic
29	Ji, Mingfang	Cancer Research Institute on Zhongshan City	Tingdong Li, Fugui Li	Establishment and validation of a two-step screening scheme for improved performance of serological screening of nasopharyngeal carcinoma	Clinical
30	Jia, Lin	The University of Hong Kong	Yim Ling Yip, Weitao Lin, Kit San Yuen, Dong-Yan Jin, George SW Tsao	Regulation of lytic Epstein- Barr virus replication in a newly established nasopharyngeal cancer cell line	Basic

Poster Session 2: Tuesday June 26th, 2:00-4:00 pm
#	Name	Affiliation	Co-Author(s)	Title	Category
01	Keppen, Chenole	Healthcare Laboratory and Research Centre, Naga Hospital Authority Kohima	Vinotsole Khamo, Wetetsho Kapfo, Subhash Medhi	Association of HSPA1B with nasopharyngeal carcinoma in Naga population of Northeast India	Clinical
02	Khamo, Vinotsole	Naga Hospital Authority Kohima	Visenuo Aiko, Chenole Keppen	EBV determination of Nasopharyngeal Carcinoma in Naga population of North-East India	Clinical
03	Khoo, Alan	Institute for Medical Research	Norazlin Abdul Aziz, Ng Wooi Loon, Johnny SH Kwan, Cheng-Eng Koay, Kwok-Wai Lo, Munirah Ahmad, Alan Soo-Beng Khoo	Spontaneous Lytic Reactivation of Epstein- Barr virus in lymphoid xenografts from nasopharyngeal carcinoma patients	Translational
04	Ko, Josephine	The University of Hong Kong	Maria Li Lung	Telomere length associates with risk of NPC and survival of late stage IV patients	Translational
05	Kontny, Udo	RWTH University Hospital Aachen	Anna Makowska, Lora Wahab, Till Braunschweig, Nikiforos-Ioannis Kapetanakis, Christian Vokuhl, Bernd Denecke, Lian Shen, Pierre Busson	Interferon beta induces apoptosis in nasopharyngeal carcinoma cells via the TRAIL- signaling pathway	Basic
06	Lee, Hui Min	University of Malaya	APE Sia, H Sathasivam, GSW Tsao, PG Murray, IC Paterson, LF Yap	Downregulation of monoamine oxidase A (MAOA) by EBV infection promotes NPC cell migration	Basic
07	Leong, Man Long	The University of Hong Kong	Arthur Kwok Leung Cheung, Wei Dai, Sai Wah Tsao, Maria Li Lung	EBV-associated histone modifications in the regulation of DNA damage repair members resulting in cisplatin resistance in nasopharyngeal carcinoma	Basic

08	Li, Lili	The Chinese University of Hong Kong	Xu J, Wang Z, Qiu G, Ying J, Du Z, Chan AT, Chan FKL, Ambinder RF, Tao Q	Epigenomic identification and functional characterization of novel tumor suppressor genes (TSGs): a p53-regulated 3p22.2 TSG represses oncogenic STAT3 signaling via protein docking	Basic
09	Li, Shibing	Sun Yat-Sen University Cancer Center	Li Yuan, Yanyan Liu, Jianhua Sui, Qian Zhong, Musheng Zeng	ISNLx regulates cellular metabolic reprogramming and is a potential therapeutic target for nasopharyngeal carcinoma	Translational
10	Li, Yongshu	The University of Hong Kong	Chanping You, Chi Man Tsang	Development of molecular probes for surface markers on LMP1-positive nasopharyngeal cancer cell using aptamer selected by Cell-SELEX	Basic
11	Lim, Chwee Ming	National University of Singapore	Anthony Kian-Fong Liou, Gwyneth Soon, Louise Tan, Wei-Kin Chong, Shi Wang, Chwee-Ming Lim	IL18 from NPC induced PD-1 expression on NK cells in TILS leading to poor prognosis	Translational
12	Liu, Na	Sun Yat-Sen University Cancer Center	Na Liu, Yingqin Li, Qingmei He, Xin Wen, Jun Ma	EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma	Basic
13	Liu, Tengfei	The University of Hong Kong	Pei Shin Pang, Weitao Lin, Chi-Man Tsang, Elaine Yip, Zhou Yuan, Xin-Yuan Guan, Sai- Wah Tsao, Wen Deng	Defining early events of EBV infection in immortalized nasopharyngeal epithelial cells using cell-free EBV infection	Basic
14	Liu, Xuefeng	Georgetown University		Patient-Derived Cell Models and Next Generation Living Biobanks (NGLB) for Precision Medicine	Translational
15	Lung, Hong Lok	Hong Kong Baptist University	On Ying Man	How the serum amyloid A1 (SAA1) genetic variants differentially modulate the focal adhesion in nasopharyngeal carcinoma (NPC) cells?	Basic

16	Mai, Zhi- Ming	The University of Hong Kong	Sai-Yin Ho, Roger Kai- Cheong Ngan, Dora Lai-Wan Kwong, Wai- Tong Ng Alice Wan- Ying Ng, Kam-Tong Yuen, Kai-Ming Ip, Yap- Hang Chan, Anne Wing-Mui Lee, Maria Li Lung, Tai-Hing Lam	Are exposure to sunlight, dietary vitamin D intake, serum and genetically derived 25-hydroxyvitamin D risk factors of nasopharyngeal carcinoma (NPC)?	Clinical
17	Mejia, Michael	Benavides Cancer Institute	Ryan Anthony F Agas, Paolo G Sogono	Outcomes with Reirradiation for Recurrent Nasopharyngeal Carcinomas: Experience from a Tertiary Academic Center in a Developing Country	Clinical
18	Ngernsomb at, Chawalit	Mahidol University	Warut Tulalamba, Noppadol Larbcharoensub, Tavan Janvilisri	Transcriptomic profiling reveals potential biomarkers for recurrence of nasopharyngeal carcinoma	Translational
19	Ning, Lvwen	The University of Hong Kong	Josephine Mun Yee Ko, Maria Li Lung	Targeted gene sequencing studies of CDKN2B-AS1 in nasopharyngeal carcinoma genetic susceptibility	Translational
20	Paramita, Dewi Kartikawati	Universitas Gadjah Mada	Fachiroh J, Sumartiningsih, Suhda S, Kiely S, Herdini C, Ardiningtyas B	NPC Strip G: Rapid Test Strip Detecting IgG against EBV Antigens in NPC	Clinical
21	Paterson, Ian	University of Malaya	Tan ML, Parkinson EK, Yap LF	Relationship between autophagy, activation and senescence in normal and cancer-associated fibroblasts from the head and neck	Basic
22	Prattapong, Pongphol	Mahidol University	Thana Narkthong, Alisa Damnernsawad, Supeecha Kumkate, Tavan Janvilisri	Anticancer activities of baicalein against nasopharyngeal carcinoma	Basic
23	Qi, Xuekang	Sun Yat-Sen University Cancer Center	Hui-Qiong Han, Hao- Jiong Zhang, Miao Xu, Lili Li, Lin Chen, Tong Xiang, Qi-Sheng Feng, Tiebang Kang, Chao- Nan Qian, Mu-Yan Cai, Qian Tao, Yi-Xin Zeng, Lin Feng	OVOL2 links stemness and metastasis via fine-tuning epithelial-mesenchymal transition in nasopharyngeal carcinoma	Basic

24	Ruuskanen, Miia	Turku University Hospital	Irjala H, Minn H, Vahlberg T, Randen- Brady R, Hagstrom J, Syrjanen S, Leivo I	Epstein-Barr virus and human papillomaviruses are favourable prognostic factors in Finnish nasopharyngeal carcinoma – a nationwide study	Clinical
25	Shair, Kathy Ho Yen	University of Pittsburgh	Elizabeth A. Caves, Sarah A. Cook, Phillip Ziegler, Nara Lee, Donna Stolz, Simon Watkins and Kathy H.Y. Shair	Application of the air liquid interface (ALI) culture method to study EBV pathogenesis in polarized airway epithelia	Basic
26	Tang, Wing Chung	The University of Hong Kong	Anna CM Tsang, J Zhang, CP You, Gareth E Jones, George SW Tsao	Induction of invadosomes formation in EBV-infected nasopharyngeal carcinoma cells by M2 macrophages and LMP1 expression	Basic
27	Tian, Jinxiu	Sun Yat-Sen University Cancer Center	Hao-Jiong Zhang, Jinxiu Tian, Xue-Kang Qi, Tong Xiang, Gui- Ping He, Hua Zhang, Xibao Yu, Xiao Zhang, Bingchun Zhao, Qi- Sheng Feng, Ming- Yuan Chen, Musheng Zeng, Yi-Xin Zeng and Lin Feng	Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation	Basic
28	Tsai, Ming- Han	National Yang-Ming University	Zhe Li, Ming-Han Tsai, Remy Poirey, Anatoliy Shumilov, Henri- Jacques Delecluse	The M81 Epstein-Barr virus associated RNA 2 enhances CXCL8 production and spontaneous virus lytic replication in primary B lymphocytes	Basic
29	Tsang, Anna Chi- Man	The University of Hong Kong	Wilson WC Tang, Gareth E Jones, George SW Tsao	The impact of invadosomes in promoting the invasiveness of nasopharyngeal carcinoma (NPC) under the interplay of stromal macrophages and EBV infection	Basic
30	Tay, Joshua	Stanford University School of Medicine	Chunfang Zhu, Shirley Zhu, Sujay Vennam, Joseph Foley, Quynh- Thu Le, John Sunwoo, Robert West	Gene expression in nasopharyngeal carcinoma by laser capture microdissected transcriptome sequencing	Translational

Poster Session 3: Wednesday June 27th, 4:00-6:00 pm
#	Name	Affiliation	Co-Author(s)	Poster Title	Category
01	Wang, Fang	Sun Yat-Sen University Cancer Center	Fang Wang, Tong-Min Wang, Jiang-Bo Zhang, Wei-Hua Jia	Germline mutations in DNA polymerase POLN are associated with familial nasopharyngeal carcinoma	Translational
02	Wang, Tongmin	Sun Yat-Sen University Cancer Center	Tong-Min Wang; Guo- Ping Shen; Ming-Yuan Chen; Jiang-Bo Zhang; Ying Sun;Wei-Hua Jia	A prospective multi-stage study identified CEP128 as a susceptibility gene for radiation-induced brain injury	Clinical
03	Wang, Ya- Qin	Sun Yat-Sen University Cancer Center	Yu-Pei Chen, Yu Zhang, Wei Jiang, Na Liu, Jing-Ping Yun, Ying Sun, Qing-Mei He, Xin- Ran Tang, Xin Wen, Xiao-Jing Yang	Prognostic significance of tumor-infiltrating lymphocytes in nondisseminated nasopharyngeal carcinoma: A large-scale cohort study	Clinical
04	Wong, Wee Lin	University of Malaya	Lee HM, Tsao GSW, Haigh T, Murray PG, Taylor G, Khoo AS, Yap LF, Paterson IC	Influence of cancer- associated fibroblasts on immune evasion in NPC	Basic
05	Xiang, Tong	Sun Yat-Sen University Cancer Center	Wen-Long Ma, Hao- Jiong Zhang, Ke-Ming Chen, Gui-Ping He, Qi- Sheng Feng, Yi-Xin Zeng, Lin Feng.	A role of EBV in vascular mimicry formation via AKT/HIF-1a pathway in EBV-associated epithelial malignancies	Translational
06	Xu, Miao	Sun Yat-Sen University Cancer Center	You-Yuan Yao, Shanshan Zhang, Su- Mei Cao, Zhe Zhang, Weimin Ye, Hans-Olov Adami, Xihong Lin, Jianjun Liu, Yi-Xin Zeng	Genome sequencing analysis identifies Epstein- Barr virus subtypes associated with the risk of nasopharyngeal carcinoma	Clinical
07	Xue, Zhichao	The University of Hong Kong		Preclinical study of PD- 0332991 on EBV-positive NPC cell lines and xenografts	Translational
08	Yap, Lee Fah	University of Malaya	Lee HM, Haigh T, Wong WL, Tsao GSW, Murray PG, Taylor G, Paterson IC, Yap LF	The contribution of Epstein-Barr virus to the impaired T-cell responses in nasopharyngeal carcinoma	Basic
09	Yip, Yim Ling	The University of Hong Kong	Weitao Lin, Wen Deng, Lin Jia, Kwok Wai Lo, Pierre Busson, Benjamin Vérillaud, Xuefeng Liu, Chi Man Tsang, Maria Li Lung, Sai Wah Tsao	Establishment of a nasopharyngeal carcinoma cell line capable to undergo EBV lytic reactivation	Basic

10	Yiu, Stephanie	The University of Hong Kong	Pei Tung Yiu, Kwai Fung Hui, Chung King Choi, Richard Yi Tsun Kao, Dan Yang and Alan Kwok Shing Chiang	Autophagy is essential in promoting EBV lytic reactivation by a novel compound, C7, in EBV- positive nasopharyngeal carcinoma	Basic
11	You, Chanping	The University of Hong Kong	Wilson WC Tang, Gareth E Jones, George SW Tsao, Anna CM Tsang	Topographic guidance of the formation of invadopodia in EBV- infected nasopharyngeal epithelial cells induced by TGF-beta1	Basic
12	Warren, Marshelle	Viracta Therapeutics, Inc.	Robert McRae, Preston Daniels	Epigenetic regulation of Epstein Barr virus: a promising therapeutic target for the treatment of nasopharyngeal carcinoma	Translational
13	Zhang, Jiang-bo	Sun Yat-Sen University Cancer Center	Wang Tong-Min, Huang Shao-Yi, Dong Si-Qi, He Yong-Qiao and Jia Wei-Hua	Natural variations in BRLF1 promoter from nasopharyngeal carcinoma endemic areas contributes to the elevated reactivation level of Epstein-Barr virus	Clinical
14	Zhang, Jun	The University of Hong Kong	Lin Jia, Tengfei Liu, Yim Ling Yip, Wing Chung Tang, Weitao Lin, Wen Deng, Kwok Wai Lo, Chanping You, Maria Li Lung, Gareth E Jones, Lai-Man Cheung, Chi Man Tsang, Sai Wah Tsao	Epstein-Barr virus-encoded LMP1 reprograms glucose metabolism to drive cell motility through mTORC2/PDHE1a- mediated histone acetylation in nasopharyngeal cells	Basic
15	Zhang, Xiao	Sun Yat-Sen University Cancer Center	Bingchun Zhao, Mingmei Ding, Haojiong Zhang, Xibao Yu, Tong Xiang, Ling Gao, Miao Xu, Lin Feng, Qisheng Feng, Musheng Zeng, Qinjian Zhao, Yixin Zeng.	A novel vaccine candidate based on chimeric VLP displaying multiple conserved epitopes induce neutralizing antibodies against EBV infection	Translational

16	Zhao, Bing- chun	Sun Yat-Sen University Cancer Center	Xiao Zhang, Claude Krummenacher, Shuo Song, Ling Gao, Haojiong Zhang, Miao Xu, Lin Feng, Qisheng Feng, Musheng Zeng, Yuting Xu, Yixin Zeng	Immunization with Fc- based recombinant Epstein-Barr virus gp350 elicits potent neutralizing humoral immune response in a BALB/c mice model	Translational
17	Zhong, Qian	Sun Yat-Sen University Cancer Center	Zhi-Hua Liu, Zhi-Rui Lin, , Li Yuan, Yan-min Liu, Ai-Jun Zhou, Xin- Yuan Guan, Ling Guo, Hai-Qiang Mai, Ming- Yuan Chen, Fei Han, Yun-Fei Xia, Mu-Sheng Zeng	The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma	Translational
18	Zhu, Junyu	The Chinese University of Hong Kong	Chi-Hang Wong, Brigette B.Y. Ma, Connie W.C. Hui, Kwok-Wai Lo, Edwin P. Hui, Anthony T.C. Chan	Preclinical evaluation of the synergistic effects of LEE011 and BYL719 in nasopharyngeal carcinoma	Translational
19	Zhu, Qian- Ying	Sun Yat-Sen University Cancer Center	Jiang-Yi He, Mu-Sheng Zeng	Overexpression of Nogo receptor 3 (NgR3) correlates with poor prognosis and contributes to the migration of epithelial cells of nasopharyngeal carcinoma patients	Translational
20	Cho, William	Queen Elizabeth Hospital	Victor Wan-San Ma	A multiplex fluorescent application for the co- localization of Epstein-Barr viral RNA and xenobiotic detoxification enzyme in nasopharyngeal carcinoma and lymphoepithelioma-like carcinoma of lung	Basic
21	Lui, Vivian	The Chinese University of Hong Kong	Hoi-Lam Ngan, Lan Wang, Kwok-Wai Lo	Re-analysis of whole- exome sequencing data of EBV(+) NPC and HPV(+) HNSCC reveals genomic commonalities in major patient subsets	Translational
22	Lin, Su- Fang	National Health Research Institutes	Abstract link	Comparativetranscriptomic analysis ofNP460hTert andNP550hTert with or withoutEBV infection	conference program link

23	Cheung, Lydia WT	The University of Hong Kong
24	Chua, Melvin LK	National Cancer Centre Singapore
25	Liu, Xu	Sun Yat-Sen University Cancer Center
26	Wu, Dinglan	Shenzhen Hospital, The Southern Medical University
27	Zhang, Yuan	Sun Yat-Sen University Cancer Center

0621 楔子 + 行前預習

好快，又二年了!

• 回來後記得將NP460hTert reads拉出來，和GA514後面五株細胞統一做alignment
• 考慮做下一批RNA-seq時, 是否要treat NP460hTert, NP550hTert with TGFB1 24h
• miRNAs 要進來嗎?
• Immune evasions
• viral parts BNLF2a, vIL10, miRNAs?
• host parts (don't eat me (CD47) eat me (CALR)
• Kathy HY Shair @ U Pittsburg (過去與Nancy Raab-Traub做過), 建議我們要注意Ca++濃度宜在0.8-0.9 mM, 並且 Venn Diagram要一個一個做

0625 Monday (Day 2) 

EBV Infection and NPC Pathogenesis
led by Alan Chiang (The University of Hong Kong, Hong Kong SAR China)

• Latency II, LMP1+ LMP1- LMP1+ LMP1 highly heterogeneous
• MHC I gene mutation. NFKB
• How EBV contributes to NPC : some critical questions
• are pathogenic EBV variants linked to NPC ?
• – Prof Paul Farrell on variation of EBV genomic sequence
• – Dr. Xu Miao on EBV subtypes in NPC (Poster 7)
• Lytic activity of EBV in epithelium and NPC
• – Prof Bill Sugden on how EBV prevails during productive infection
• – Shannon Kenny
• Viral and host factors
• – Rebecca Skalskyon regulation of host signaling pathways by EBV miRNAs
• – Dr. Feng Lin on TFNR
• – Epigenetic
• – Cancer heterogeneity

Regulation of Lytic and Latent EBV Infection
led by Mei-Ru Chen (National Taiwan University, Taiwan)
(list contributions and achievements of each speakers, very nice!)

Group Photo